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N cells incubated in the absence or presence of IGF-1 in the presence of the MEK inhibitor but there was a significant protective effect of IGF-1 against anoikis in the presence of the MEK inhibitor as evidenced by its ability to prevent PARPLuey and May Molecular Cancer (2016) 15:Page 9 ofAPhosphorylated IGF receptor 95 kDacleavage. These data demonstrate that the protective effect of IGF-1 again

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